ELK Biotechnology Cleaved-Notch 4 (V1432) rabbit pAb
Cleaved-Notch 4 (V1432) rabbit pAb는 인간 NOTCH4 유래 펩타이드로 제작된 폴리클로날 항체로, WB와 ELISA에 적합합니다. 세포막 및 핵에서 Notch4 단백질을 검출하며, 혈관·신장·간 발달 연구에 유용합니다. -20°C에서 1년 보관 가능합니다.
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- ES6409-xxxxx (2개 옵션)
- 판매단위
- pk
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제품명
Cleaved-Notch 4 (V1432) rabbit pAb
제품 정보
| 항목 | 내용 |
|---|---|
| Alternative Names | NOTCH4; INT3; Neurogenic locus notch homolog protein 4; Notch 4; hNotch4 |
| Applications | WB; ELISA |
| Recommended Dilutions | Western Blot: 1/500 - 1/2000 ELISA: 1/5000 Not yet tested in other applications |
| Immunogen | The antiserum was produced against synthesized peptide derived from human NOTCH4. AA range: 1401–1450 |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 59 kD |
| Gene ID (Human) | 4855 |
| Human Swiss-Prot No. | Q99466 |
| Cellular Localization | Cell membrane; Single-pass type I membrane protein. [Notch 4 intracellular domain]: Nucleus. Following proteolytical processing NICD is translocated to the nucleus. |
| Species Reactivity | Human; Mouse; Monkey |
Background
notch 4 (NOTCH4), Homo sapiens
This gene encodes a member of the NOTCH family of proteins. Members of this type I transmembrane protein family share structural characteristics including an extracellular domain consisting of multiple epidermal growth factor-like (EGF) repeats and an intracellular domain consisting of multiple different domain types.
Notch signaling is an evolutionarily conserved intercellular signaling pathway that regulates interactions between physically adjacent cells through binding of Notch family receptors to their cognate ligands.
The encoded preproprotein is proteolytically processed in the trans-Golgi network to generate two polypeptide chains that heterodimerize to form the mature cell-surface receptor. This receptor may play a role in vascular, renal, and hepatic development. Mutations in this gene may be associated with schizophrenia. Alternative splicing results in multiple transcript variants.
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