ELK Biotechnology NFκB-p105/p50 (phospho Ser337) rabbit pAb
NFκB-p105/p50 (phospho Ser337) rabbit polyclonal antibody로, 인간 NF-κB p105/p50의 Ser337 인산화 부위를 인식합니다. WB, IHC, IF, ELISA에 적합하며, 핵과 세포질에서 발현되는 NF-κB 단백질 연구에 유용합니다.
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제품명
NFκB-p105/p50 (phospho Ser337) rabbit pAb
제품 정보
| 항목 | 내용 |
|---|---|
| Alternative Names | NFKB1; Nuclear factor NF-kappa-B p105 subunit; DNA-binding factor KBF1; EBP-1; Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 |
| Applications | WB; IHC; IF; ELISA |
| Recommended Dilutions | Western Blot: 1/500–1/2000 Immunohistochemistry: 1/100–1/300 Immunofluorescence: 1/200–1/1000 ELISA: 1/20000 Not yet tested in other applications. |
| Immunogen | Synthesized peptide derived from human NF-κB p105/p50 around the phosphorylation site of Ser337 (AA range: 304–353). |
| Host | Rabbit |
| Storage | -20°C, 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Gene ID (Human) | 4790 |
| Human Swiss-Prot No. | P19838 |
| Cellular Localization | Nucleus; Cytoplasm. Found in the nucleus and cytoplasm in an inactive form complexed to an inhibitor (I-kappa-B). |
| Species Reactivity | Human; Mouse; Rat |
Background
Nuclear factor kappa B subunit 1 (NFKB1) is a human gene encoding a 105 kDa protein that undergoes cotranslational processing by the 26S proteasome to yield a 50 kDa protein. The 105 kDa form acts as a Rel protein-specific transcription inhibitor, while the 50 kDa form serves as a DNA-binding subunit of the NF-κB complex. NF-κB is a transcription regulator activated by diverse stimuli such as cytokines, reactive oxygen species, UV irradiation, and bacterial or viral products. Activated NF-κB translocates to the nucleus to induce expression of genes involved in immune and inflammatory responses. Dysregulation of NF-κB activity is linked to inflammatory diseases and abnormal immune cell development.
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