ELK Biotechnology Rho B rabbit pAb
Rho B 단백질을 인식하는 토끼 폴리클로날 항체로, WB, ELISA, IHC에 적합합니다. 인간 RHOB 유래 합성 펩타이드로 면역화되었으며, 세포막 및 핵 등 다양한 세포 위치에서 발현 탐지에 활용됩니다. 암 연구 및 세포 신호 전달 연구에 유용합니다.
- 판매단위
- pk
카탈로그
2개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다ELK Biotechnology · ELK Biotechnology Rho B rabbit pAb
ELK Biotechnology Rho B rabbit pAb
제품 정보
| 항목 | 내용 |
|---|---|
| Product name | Rho B rabbit pAb |
| Alternative Names | RHOB; ARH6; ARHB; Rho-related GTP-binding protein RhoB; Rho cDNA clone 6; h6 |
| Applications | WB; ELISA; IHC |
| Recommended Dilutions | WB 1:500–2000; IHC-p 1:50–300; ELISA 1:2000–1:20000 |
| Immunogen | The antiserum was produced against synthesized peptide derived from human RHOB. AA range: 99–148 |
| Storage | -20°C / 1 year |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 22 kDa |
| GeneID (Human) | 388 |
| Human Swiss-Prot No. | P62745 |
| Cellular Localization | Late endosome membrane; Lipid-anchor. Cell membrane; Lipid-anchor. Nucleus. Cleavage furrow. Late endosomal membrane (geranylgeranylated form). Plasma membrane (farnesylated form). Also detected at the nuclear margin and in the nucleus. Translocates to the equatorial region before furrow formation in an ECT2-dependent manner. |
| Species Reactivity | Human; Mouse; Rat |
Background
Function: Mediates apoptosis in neoplastically transformed cells after DNA damage. Not essential for development but affects cell adhesion and growth factor signaling in transformed cells. Plays a negative role in tumorigenesis as deletion causes tumor formation. Involved in intracellular protein trafficking of a number of proteins. Targets PKN1 to endosomes and is involved in trafficking of the EGF receptor from late endosomes to lysosomes. Also required for stability and nuclear trafficking of AKT1/AKT which promotes endothelial cell survival during vascular development.
Miscellaneous: RHOB is one of the targets of farnesyltransferase inhibitors currently under investigation as cancer therapeutics. These inhibitors elevate the levels of geranylgeranylated RHOB and cause mislocalization, leading to apoptosis and antineoplastic effects.
PTM: Prenylation specifies the subcellular location of RHOB. The farnesylated form is localized to the plasma membrane while the geranylgeranylated form is localized to the endosome.
Similarity: Belongs to the small GTPase superfamily, Rho family.
Subunit: Binds ROCK1 and ROCK2. Also binds PKN1/PRK1. Interacts with ARGGEF3, RTKN, and AKAP13.
ELK Biotechnology 상품 둘러보기
전체보기
문의
0개 · 배송·재고 문의는 실시간 상담이 빠릅니다아직 등록된 문의가 없어요.