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ELK Biotechnology Flk-1/Flt-4 (phospho Tyr1054/Y1063) rabbit pAb
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VEGF 수용체 관련 인산화 부위(Tyr1054/Y1063)를 인식하는 rabbit polyclonal antibody로, 인간·마우스·랫에서 반응합니다. IHC, IF, ELISA에 사용 가능하며 고농도(1 mg/ml)로 제공됩니다. VEGFR2 신호 연구 및 혈관 내피 성장 인자 관련 연구에 적합합니다.
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- pk
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ELK Biotechnology ES6019-100UL Flk-1/Flt-4 (phospho Tyr1054/Y1063) rabbit pAb, 100UL pk판매 단위 pk ·
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402,000원VAT 포함 442,200원
ELK Biotechnology ES6019-50UL Flk-1/Flt-4 (phospho Tyr1054/Y1063) rabbit pAb, 50UL pk판매 단위 pk ·
재고 확인 필요
301,000원VAT 포함 331,100원
ELK Biotechnology · ELK Biotechnology Flk-1/Flt-4 (phospho Tyr1054/Y1063) rabbit pAb
제품명
Flk-1/Flt-4 (phospho Tyr1054/Y1063) rabbit pAb
공급업체
ELK Biotechnology
제품 정보
| 항목 | 내용 |
|---|---|
| Alternative Names | KDR; FLK1; VEGFR2; Vascular endothelial growth factor receptor 2; VEGFR-2; Fetal liver kinase 1; FLK-1; Kinase insert domain receptor; KDR; Protein-tyrosine kinase receptor flk-1; CD antigen CD309; FLT4; VEGFR3; Vascular endothelial growth |
| Applications | IHC; IF; ELISA |
| Recommended Dilutions | Immunohistochemistry: 1/100 - 1/300 ELISA: 1/40000 Not yet tested in other applications |
| Immunogen | Synthesized peptide derived from human VEGFR2 around the phosphorylation site of Tyr1054 (AA range: 1020–1069) |
| Species Reactivity | Human; Mouse; Rat |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| GeneID (Human) | 3791 / 2324 |
| Human Swiss-Prot No | P35968 / P35916 |
| Cellular Localization | Cell junction, Endoplasmic reticulum, Cell membrane. Localized with RAP1A at cell-cell junctions (By similarity). Colocalizes with ERN1 and XBP1 in the endoplasmic reticulum in endothelial cells in a VEGF-dependent manner (PubMed:23529610). Isoform 1: Cell membrane; Single-pass type I membrane protein. Cytoplasm. Nucleus. Cytoplasmic vesicle. Early endosome. Detected on caveolae-enriched lipid rafts at the cell surface. Is recycled from the plasma membrane to endosomes and back again. Phosphorylation triggered by VEGFA binding promotes internalization and subsequent degradation. VEGFA binding triggers internalization and translocation to the nucleus. Isoform 2: Secreted. Isoform 3: Secreted. |
| Background | Vascular endothelial growth factor (VEGF) is a major growth factor for endothelial cells. This gene encodes one of the two receptors of VEGF, known as kinase insert domain receptor, a type III receptor tyrosine kinase. It mediates VEGF-induced endothelial proliferation, survival, migration, tubular morphogenesis, and sprouting. Signaling and trafficking are regulated by multiple factors including Rab GTPase, P2Y purine nucleotide receptor, integrin αVβ3, and T-cell protein tyrosine phosphatase. Mutations are implicated in infantile capillary hemangiomas. (RefSeq, May 2009) |
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