ELK Biotechnology KIR6.2 (phospho Thr224) rabbit pAb
KIR6.2 (phospho Thr224) rabbit polyclonal antibody로, 인산화 Thr224 부위를 인식합니다. WB, IHC, IF, ELISA에 적합하며, 인간, 마우스, 랫트 시료에 반응합니다. 막 단백질 연구 및 당뇨 관련 단백질 분석에 유용합니다.
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제품명
KIR6.2 (phospho Thr224) rabbit pAb
제품 개요
본 항체는 인간 Kir6.2 단백질의 Thr224 인산화 부위를 인식하도록 합성된 펩타이드로부터 제작된 rabbit polyclonal antibody입니다. Kir6.2는 ATP-sensitive inward rectifier potassium channel로, 세포막을 통한 칼륨 이온 이동 조절에 관여합니다.
제품 정보
| 항목 | 내용 |
|---|---|
| Product Name | KIR6.2 (phospho Thr224) rabbit pAb |
| Alternative Names | KCNJ11; ATP-sensitive inward rectifier potassium channel 11; IKATP; Inward rectifier K(+) channel Kir6.2; Potassium channel; inwardly rectifying subfamily J member 11 |
| Applications | WB; IHC; IF; ELISA |
| Recommended Dilutions | WB: 1/500–1/2000 IHC: 1/100–1/300 IF: 1/200–1/1000 ELISA: 1/5000 Not yet tested in other applications |
| Immunogen | Synthesized peptide derived from human Kir6.2 around phosphorylation site Thr224 (AA 190–239) |
| Host | Rabbit |
| Storage | -20°C, 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 40 kDa |
| Gene ID (Human) | 3767 |
| Human Swiss-Prot No. | Q14654 |
| Cellular Localization | Membrane; Multi-pass membrane protein |
| Species Reactivity | Human; Mouse; Rat |
Background
Potassium channels are present in most mammalian cells and participate in various physiological responses. The Kir6.2 protein is an inward-rectifier potassium channel controlled by G-proteins and associated with the sulfonylurea receptor SUR. Mutations in this gene can cause familial persistent hyperinsulinemic hypoglycemia of infancy (PHHI) and may contribute to disorders such as type II diabetes mellitus (NIDDM), transient neonatal diabetes mellitus type 3 (TNDM3), and permanent neonatal diabetes mellitus (PNDM). Multiple alternatively spliced transcripts have been identified.
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