ELK Biotechnology KIR3.1 rabbit pAb
KIR3.1 단백질을 인식하는 토끼 폴리클로날 항체로, WB 및 IHC에 적합합니다. G단백질 활성화 내향성 칼륨 채널 연구에 활용되며, 심장박동 및 신경전달 관련 연구에 유용합니다. -20°C에서 1년 보관 가능합니다.
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제품명
KIR3.1 rabbit pAb
제품 정보
| 항목 | 내용 |
|---|---|
| Alternative Names | KCNJ3; GIRK1; G protein-activated inward rectifier potassium channel 1; GIRK-1; Inward rectifier K(+) channel Kir3.1; Potassium channel; inwardly rectifying subfamily J member 3 |
| Applications | WB; IHC |
| Recommended Dilutions | WB 1:500–2000; IHC-p 1:50–300 |
| Immunogen | The antiserum was produced against synthesized peptide derived from human GIRK1/KIR3.1/KCNJ3. AA range: 151–200 |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 56 kD |
| Gene ID (Human) | 3760 |
| Human Swiss-Prot No | P48549 |
| Cellular Localization | Membrane; Multi-pass membrane protein |
| Species Reactivity | Human; Mouse; Rat |
Background
Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium channel. The encoded protein, which has a greater tendency to allow potassium to flow into a cell rather than out of a cell, is controlled by G-proteins and plays an important role in regulating heartbeat. It associates with three other G-protein-activated potassium channels to form a heteromultimeric pore-forming complex that also couples to neurotransmitter receptors in the brain and whereby channel activation can inhibit action potential firing by hyperpolarizing the plasma membrane. These multimeric G-protein-gated inwardly-rectifying potassium (GIRK) channels may play a role in the pathophysiology of epilepsy, addiction, and Down's syndrome.
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