ELK Biotechnology KIR3.1 (phospho Ser185) rabbit pAb
KIR3.1 (phospho Ser185) rabbit pAb는 인간 GIRK1/KCNJ3 단백질의 인산화 Ser185 부위를 인식하는 폴리클로날 항체입니다. WB, IHC, IF, ELISA에 적합하며 세포막 단백질 검출에 유용합니다. -20°C에서 1년 보관 가능.
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제품명
KIR3.1 (phospho Ser185) rabbit pAb
공급업체
ELK Biotechnology
제품 정보
| 항목 | 내용 |
|---|---|
| Alternative Names | KCNJ3; GIRK1; G protein-activated inward rectifier potassium channel 1; GIRK-1; Inward rectifier K(+) channel Kir3.1; Potassium channel; inwardly rectifying subfamily J member 3 |
| Applications | WB; IHC; IF; ELISA |
| Recommended Dilutions | Western Blot: 1/500 - 1/2000 Immunohistochemistry: 1/100 - 1/300 Immunofluorescence: 1/200 - 1/1000 ELISA: 1/20000 Not yet tested in other applications |
| Immunogen | Synthesized peptide derived from human GIRK1/KIR3.1/KCNJ3 around the phosphorylation site of Ser185 (AA range: 151–200) |
| Storage | -20°C / 1 year |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 50 kD |
| GeneID (Human) | 3760 |
| Human Swiss-Prot No | P48549 |
| Cellular Localization | Membrane; Multi-pass membrane protein |
| Species Reactivity | Human; Mouse; Rat; Monkey |
Background
Potassium channels are present in most mammalian cells and participate in a wide range of physiological responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium channel. It allows potassium to flow into a cell rather than out, controlled by G-proteins, and plays a key role in regulating heartbeat. It forms a heteromultimeric complex with other G-protein-activated potassium channels, coupling to neurotransmitter receptors in the brain. Channel activation inhibits action potential firing by hyperpolarizing the plasma membrane. These multimeric G-protein-gated inwardly rectifying potassium (GIRK) channels may be involved in the pathophysiology of epilepsy, addiction, and Down’s syndrome.
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