ELK Biotechnology ROM-K rabbit pAb
ROM-K rabbit pAb는 사람, 마우스, 랫트에서 반응하는 다클론 항체로, WB와 IHC 분석에 적합합니다. 인간 ROMK/Kir1.1 유래 펩타이드로 면역화되어 칼륨 채널 연구에 유용하며, 세포막 단백질 발현 및 인산화 연구에 활용 가능합니다.
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ELK Biotechnology ROM-K rabbit pAb
제품 개요
ROM-K rabbit pAb는 인간 ROMK/Kir1.1 단백질에서 유래한 합성 펩타이드(AA 11–60)를 면역원으로 제작된 다클론 항체입니다. 세포막에 위치한 inward-rectifier type 칼륨 채널 연구에 적합하며, WB 및 IHC 실험에 사용됩니다.
제품 스펙
| 항목 | 내용 |
|---|---|
| Product name | ROM-K rabbit pAb |
| Alternative Names | KCNJ1; ROMK1; ATP-sensitive inward rectifier potassium channel 1; ATP-regulated potassium channel ROM-K; Inward rectifier K(+) channel Kir1.1; Potassium channel; inwardly rectifying subfamily J member 1 |
| Applications | WB; IHC |
| Recommended Dilutions | WB 1:500–2000; IHC-p 1:50–300 |
| Immunogen | Synthesized peptide derived from human ROMK/Kir1.1 (AA range: 11–60) |
| Host | Rabbit |
| Storage | -20°C, 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| GeneID (Human) | 3758 |
| Human Swiss-Prot No. | P48048 |
| Cellular Localization | Cell membrane; Multi-pass membrane protein. Phosphorylation at Ser-44 by SGK1 is necessary for its expression at the cell membrane. |
| Species Reactivity | Human; Mouse; Rat |
Background
Potassium channels are present in most mammalian cells, where they participate in a wide range of physiological responses. The ROMK/Kir1.1 protein is an integral membrane protein functioning as an inward-rectifier potassium channel. It is activated by internal ATP and plays a key role in potassium homeostasis by preferentially allowing potassium influx. Mutations in this gene are associated with antenatal Bartter syndrome, characterized by salt wasting, hypokalemic alkalosis, hypercalciuria, and low blood pressure. Multiple transcript variants encoding different isoforms have been identified.
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