ELK Biotechnology Kv4.2 (phospho Ser616) rabbit pAb

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Kv4.2 (phospho Ser616) rabbit pAb

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세포 내 위치

Cell membrane; Multi-pass membrane protein. Cell projection (dendrite), cell junction (synapse), perikaryon, dendritic spine, and postsynaptic cell membrane.
In neurons, primarily detected on dendrites, dendritic spines, and neuron cell bodies, but not on axons.
Localized preferentially at dendrites of pyramidal cells in the hippocampus CA1 layer.
Detected at GABAergic synapses and at cell junctions distinct from synaptic contacts.
Detected in lipid rafts and primarily at the endoplasmic reticulum or Golgi when expressed alone (PubMed:15454437).
Interaction with KCNIP1, KCNIP2, KCNIP3, or KCNIP4 promotes expression at the cell membrane (PubMed:15454437, PubMed:24811166).
Interaction with DPP6 or related proteins also influences localization.

배경 (Background)

Voltage-gated potassium (Kv) channels are a complex class of ion channels with diverse physiological functions, including regulation of neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume control.
Four sequence-related potassium channel genes — shaker, shaw, shab, and shal — have been identified in Drosophila, each with human homologs.
This gene encodes a member of the voltage-gated, shal-related subfamily that forms A-type potassium ion channels, which are prominent in the repolarization phase of the action potential.
This channel mediates a rapidly inactivating, A-type outward potassium current not controlled by the N terminus.