Thermo Fisher Scientific SERTAD1 Polyclonal Antibody
Rabbit Polyclonal SERTAD1 항체로, 인간 단백질에 반응하며 면역세포염색(ICC/IF)에 적합합니다. 항원 친화 크로마토그래피로 정제되었으며, PBS와 글리세롤 용액 형태로 제공됩니다. 세포주기 조절 관련 연구에 유용합니다.
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Applications
Immunocytochemistry (ICC/IF)
- Tested Dilution: 0.25–2 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant Human SERTAD1. Recombinant protein control fragment (Product #RP-107226) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.05 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping conditions | Wet ice |
| RRID | AB_2665081 |
Product Specific Information
Immunogen sequence:
TSMYDNELWAP ASEGLKPGPE DGPGKEEAPE LDEAELDYLM DVLVGTQALE RP
Highest antigen sequence identity to the following orthologs:
- Mouse: 91%
- Rat: 89%
Target Information
SEI-1, also known as SERTAD1 (SERTA domain containing 1) or TRIP-Br1 (Transcriptional regulator interacting with the PHD-bromodomain 1), is a transcriptional regulator that integrates signals from transcription factors.
At E2F-responsive promoters, SEI-1 interacts with the PHD- and bromodomains of proteins such as TIF1 and DP-1, transmitting signals to the promoter and stimulating transcriptional activity.
SEI-1 forms a multiprotein complex with E2F-1 and DP-1, with expression levels varying throughout the cell cycle. It regulates cell cycle progression via promoter control during the G1 and S phases. Additionally, SEI-1 can render the cyclin D-Cdk4 complex resistant to inhibition by p16. Overexpression of SEI-1 is implicated in squamous cell carcinomas of the head and neck.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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