Thermo Fisher Scientific SERTAD1 Polyclonal Antibody

Applications

Immunocytochemistry (ICC/IF)

• Tested Dilution: 0.25–2 µg/mL

Product Specifications

Product Specific Information

Immunogen sequence:
TSMYDNELWAP ASEGLKPGPE DGPGKEEAPE LDEAELDYLM DVLVGTQALE RP

Highest antigen sequence identity to the following orthologs:

• Mouse: 91%
• Rat: 89%

Target Information

SEI-1, also known as SERTAD1 (SERTA domain containing 1) or TRIP-Br1 (Transcriptional regulator interacting with the PHD-bromodomain 1), is a transcriptional regulator that integrates signals from transcription factors.
At E2F-responsive promoters, SEI-1 interacts with the PHD- and bromodomains of proteins such as TIF1 and DP-1, transmitting signals to the promoter and stimulating transcriptional activity.

SEI-1 forms a multiprotein complex with E2F-1 and DP-1, with expression levels varying throughout the cell cycle. It regulates cell cycle progression via promoter control during the G1 and S phases. Additionally, SEI-1 can render the cyclin D-Cdk4 complex resistant to inhibition by p16. Overexpression of SEI-1 is implicated in squamous cell carcinomas of the head and neck.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.