Thermo Fisher Scientific Cdc20 Polyclonal Antibody
Rabbit polyclonal antibody targeting human CDC20, validated for WB and IP applications. E. coli-derived immunogen, unconjugated liquid form. Stored at -20°C, suitable for research use only.
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Thermo Fisher Scientific Cdc20 Polyclonal Antibody
Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| Immunoprecipitation (IP) | 0.2–1 µL/mg of lysate |
Product Specifications
| Specification | Description |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | E. coli-derived Human CDC20 fragment |
| Conjugate | Unconjugated |
| Form | Liquid |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2902462 |
Target Information
Required for full ubiquitin ligase activity of the anaphase promoting complex/cyclosome (APC/C) and may confer substrate specificity upon the complex.
Regulated by MAD2L1: in metaphase the MAD2L1-CDC20-APC/C ternary complex is inactive, and in anaphase the CDC20-APC/C binary complex is active in degrading substrates.
The CDC20-APC/C complex positively regulates the formation of synaptic vesicle clustering at the active zone to the presynaptic membrane in postmitotic neurons.
CDC20-APC/C-induced degradation of NEUROD2 induces presynaptic differentiation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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