Thermo Fisher Scientific Septin-9 Polyclonal Antibody

Applications

Immunocytochemistry (ICC/IF)

• Tested dilution: 0.25–2 µg/mL

Product Specifications

Product Specific Information

Immunogen sequence:
PAPVSQLQSRL EPKPQPPVAE ATPRSQEATE AAPSCVGDMA DTPRDAGLKQ APASRNEKAP VDFGYVGIDS

• Highest antigen sequence identity to the following orthologs:
  • Mouse: 75%
  • Rat: 77%

Target Information

The maf oncogene was identified by structural analysis of the AS42 avian transforming retrovirus genome. The Maf family is divided into two subclasses, large Mafs (vMaf, cMaf, MafB, and Nrl) and small Mafs (MafF, MafK, and MafG). Both subclasses contain leucine zipper motifs, allowing homodimerization and heterodimerization with other bZip transcription factors. Large Mafs have an acidic transactivation domain absent in small Maf proteins.

Although small Maf proteins lack inherent transactivation activity, they can act as positive regulators of transcription by targeting transcriptionally active dimerization partners to specific DNA regulatory elements. Conversely, they can act as negative regulators by recruiting transcriptional repressors or forming homodimers that replace active dimers.

Human MafF was isolated from a human myometrium cDNA library and encodes a 164 amino acid protein. Like other small Maf proteins, it contains an extended leucine zipper structure and lacks an N-terminal transactivating domain. The three small Maf proteins are implicated in development, differentiation, hematopoiesis, and stress response, regulating stress through different mechanisms.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.