Thermo Fisher Scientific SMO Monoclonal Antibody (1G11)
SMO 단백질을 인식하는 마우스 단클론 항체(클론 1G11)로, ELISA에 최적화되어 있습니다. 인간 시료에 반응하며 비결합형 액상 형태로 제공됩니다. Hedgehog 신호전달 연구 및 SMO 단백질 발현 분석에 유용합니다.
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Applications
- ELISA (ELISA): Tested dilution 10 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 1G11 |
| Immunogen | SMO (NP_005622, 56 a.a. approximately 155 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | See Label |
| Storage Buffer | Ascites |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Sequence of this protein is as follows:
GPPPPLSHCG RAAPCEPLRY NVCLGSVLPY GATSTLLAGD SDSQEEAHGK LVLWSGLRNA PRCWAVIQPL LCAVYMPKCE NDRVELPSRT LCQATRGPCA
Target Information
Smoothened drosophila homolog (SMOH) is a serpentine protein belonging to the G-protein coupled receptor Fz/Smo family with 787 amino acids. It is a seven-transmembrane G protein-coupled receptor with four glycosylation sites and a putative extracellular amino terminus. Smoothened, activated by β-Arrestin 2 and GRK2, acts as a receptor for Sonic hedgehog (Shh) and is a positive regulator of the hedgehog signaling pathway along with the patched protein (PTCH). It regulates vertebrate developmental processes, cellular proliferation, and differentiation by activating transcription factor Gli. Mutations in Smoothened are associated with sporadic basal cell carcinoma of the skin. It is widely expressed in heart and brain tissues.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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