Thermo Fisher Scientific CDCA8 Polyclonal Antibody
Thermo Fisher Scientific의 CDCA8 Polyclonal Antibody는 인간, 마우스, 랫트 시료에 반응하며 Western blot 및 ELISA에 적합합니다. Rabbit IgG 기반의 비결합 항체로, 세포 분열 관련 단백질 CDCA8을 검출하는 데 사용됩니다. 고순도 친화 크로마토그래피 정제 제품입니다.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:200–1:2,000 |
| ELISA | 1 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host/Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fusion protein containing a sequence corresponding to amino acids 1–124 of human CDCA8 (NP_060571.1) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1.88 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol |
| Contains | 0.01% thimerosal |
| Storage Conditions | –20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2806095 |
Product Specific Information
Immunogen sequence:
MAPRKGSSRV AKTNSLRRRK LASFLKDFDR EVEIRIKQIE SDRQNLLKEV DNLYNIEILR LPKALREMNW LDYFALGGNK QALEEAATAD LDITEINKLT AEAIQTPLKS AKTRKVIQVD EMIV
Positive Samples:
A-549, 293T, Mouse testis, Rat brain
Cellular Location:
Chromosome, Cytoplasm, Nucleus, Centromere, Cytoskeleton, Nucleolus, Spindle
Target Information
CDCA8 is a component of the chromosomal passenger complex (CPC) required for the stability of the bipolar mitotic spindle. The CPC, which includes Survivin, CDCA8, INCENP, and Aurora-B, plays crucial roles during mitosis and cell division. CDCA8 interacts with Aurora-B, INCENP, and Survivin, showing increased expression during the G2/M phase and reduction after mitotic exit. It is cell cycle regulated, down-regulated by p53/Rb signaling, and up-regulated in various cancers. Inactivation of CDCA8 in Drosophila leads to polyploidy, delayed mitosis, and abnormal tissue development, highlighting its role in cell proliferation. Aberrant expression of CDCA8 is associated with poor prognosis in gastric cancer.
Safety Information
⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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