Thermo Fisher Scientific Casc5 Polyclonal Antibody

Applications

Tested Dilution

Publications

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:200

-

Immunocytochemistry (ICC/IF)

0.25-2 µg/mL

-

Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant protein corresponding to Human Casc5. Recombinant protein control fragment (Product #RP-92565). if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:CASC5,uniProtId:Q8NG31-1,ncbiNodeId:9606,antigenRange:1822-1970,antigenLength:2342,antigenImageFileName:PA5-55360_CASC5_Q8NG31-1_Rabbit.svg,antigenImageFileNamePDP:PA5-55360_CASC5_Q8NG31-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.1 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.2, with 40% glycerol

Contains

0.02% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Wet ice

RRID

AB_2639304

Product Specific Information

Immunogen sequence: HHTEEDIDKS ANSVLIKNLS RTPSSCSSSL DSIKADGTSL DFSTYRSSQM ESQFLRDTIC EESLREKLQD GRITIREFFI LLQVHILIQK PRQSNLPGNF TVNTPPTPED LMLSQYVYRP KIQIYREDCE ARRQKIEELK LSASNQDKL

Highest antigen sequence identity to the following orthologs: Mouse - 77%, Rat - 81%.

Target Information

Performs two crucial functions during mitosis: it is essential for spindle-assembly checkpoint signaling and for correct chromosome alignment. Required for attachment of the kinetochores to the spindle microtubules. Directly links BUB1 and BUB1B to kinetochores. Part of the MIS12 complex, which may be fundamental for kinetochore formation and proper chromosome segregation during mitosis. Acts in coordination with CENPK to recruit the NDC80 complex to the outer kinetochore.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.