Thermo Fisher Scientific ASAP2 Polyclonal Antibody
ASAP2 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal 항체. Western blot 및 Immunoprecipitation에 적합하며, 비결합형 액상 형태로 제공. 4°C 보관, 1년 유효기간. 연구용으로만 사용 가능.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:2,000–1:10,000 |
| Immunoprecipitation (IP) | 2–10 µg/mg lysate |
Product Specifications
| 항목 | 내용 |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region between residue 900 and 950 of human ArfGAP with SH3 domain, Ankyrin Repeat and PH Domain 2 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Storage Conditions | 4°C |
| Shipping Conditions | Wet ice |
Product Specific Information
The recommended shelf life for this product is 1 year from date of receipt.
Target Information
ASAP2 is a multidomain protein belonging to the beta family with two ANK repeats, an Arf-GAP domain, a PH domain, and an SH3 domain. It localizes in the Golgi apparatus and plasma membrane, where it colocalizes with protein tyrosine kinase 2-beta (PYK2) and forms a stable complex with PYK2 in vivo. ASAP2 is tyrosine phosphorylated by activated PYK2 and functions as a substrate and downstream target for PYK2 and SRC, possibly regulating vesicular transport.
It activates small GTPases ARF1, ARF5, and ARF6, regulating post-Golgi vesicle formation and constitutive secretion. ASAP2 also modulates Fc gamma receptor–mediated phagocytosis via ARF6. Typically detected in heart, brain, placenta, kidney, monocytes, and pancreas, it is up-regulated during monocyte maturation. Multiple transcript variants encoding different isoforms have been identified.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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