Thermo Fisher Scientific VPRBP Polyclonal Antibody
Human VPRBP 단백질을 인식하는 Rabbit Polyclonal Antibody로, IHC(P) 및 ICC/IF에 적합. 항원 친화 크로마토그래피로 정제된 액상 시약. 세포 주기 조절, 텔로머레이스 조절 및 히스톤 변형 연구에 활용 가능. 연구용으로만 사용.
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Applications
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:20–1:50
Immunocytochemistry (ICC/IF)
- Tested Dilution: 0.25–2 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human VPRBP. Recombinant protein control fragment (Product #RP-103723). |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.05 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2649449 |
Product Specific Information
Immunogen sequence:
IAHIYDIQTG NKLLTLFNPD LANNYKRNCA TFNPTDDLVL NDGVLWDVRS AQAIHKFDKF NMNISGVFHP NGLEVIINTE IWD
- Highest antigen sequence identity to orthologs: Mouse – 100%, Rat – 100%
Target Information
VPRBP acts as both a substrate recognition component of E3 ubiquitin-protein ligase complexes and as an atypical serine/threonine-protein kinase. It plays roles in cell cycle regulation, telomerase regulation, and histone modification.
Functions as a substrate-specific adapter of the CUL4A-RBX1-DDB1-DCAF1/VPRBP complex, mediating ubiquitination and degradation of proteins such as NF2.
Involved in turnover of methylated proteins, recognizing and binding methylated proteins via its chromo domain.
Participates in B-cell development by limiting error-prone repair during V(D)J recombination.
Also part of the EDVP complex, mediating ubiquitination of proteins such as TERT, leading to telomerase inhibition.
Acts as an atypical serine/threonine-protein kinase that phosphorylates Thr-120 of histone H2A (H2AT120ph), repressing transcription and down-regulating tumor suppressor genes.
Involved in JNK-mediated apoptosis during cell competition via interaction with LLGL1 and LLGL2.
During HIV-1 infection, recruited by Vpr to hijack the CUL4A-RBX1-DDB1-DCAF1/VPRBP complex, leading to G2 phase arrest and protection of viral proteins.
During HIV-2 infection, recruited by Vpx to enhance macrophage infection efficiency and viral replication.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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