Thermo Fisher Scientific FBW7 Polyclonal Antibody
FBXW7 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. 인간 및 유인원 종에 반응하며 IHC 및 IHC(Paraffin) 실험에 적합. 항원 친화 크로마토그래피로 정제된 액상 항체로, 4°C에서 보관.
- 카탈로그번호
- IHC00348x (2개 옵션)
- 판매단위
- pk
카탈로그
2개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다Thermo Fisher Scientific · Thermo Fisher Scientific FBW7 Polyclonal Antibody
Thermo Fisher Scientific FBW7 Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (IHC) | 1:100–1:500 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:100–1:500 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region between residue 50 and 100 of human F-box and WD-40 domain protein 7 (FBXW7) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.10 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | TBS, pH 7.0–8.0, with 0.1% BSA |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Wet ice |
Product Specific Information
- Recommended shelf life: 1 year from date of receipt
- Based on 100% sequence identity, predicted to react with Monkey, Gorilla, Chimpanzee, Northern white-cheeked gibbon, and Crab-eating macaque
Target Information
F-Box and WD Repeat Domain Containing 7 (FBXW7) is a member of the F-box protein family characterized by an approximately 40 amino acid motif, the F-box. These proteins form one of the four subunits of the ubiquitin protein ligase complex (SCF: SKP1–Cullin–F-box), functioning in phosphorylation-dependent ubiquitination.
F-box proteins are divided into three classes:
- Fbws: Contain WD-40 domains
- Fbls: Contain leucine-rich repeats
- Fbxs: Contain other interaction modules or no recognizable motifs
FBXW7 (previously FBX30) belongs to the Fbws class and contains seven tandem WD40 repeats. It binds directly to cyclin E and likely targets it for ubiquitin-mediated degradation. Mutations in this gene have been detected in ovarian and breast cancer cell lines, suggesting a role in cancer pathogenesis. Multiple transcript variants encoding different isoforms have been identified.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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