Thermo Fisher Scientific FBW7 Polyclonal Antibody

Thermo Fisher Scientific FBW7 Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Product Specific Information

• Recommended shelf life: 1 year from date of receipt
• Based on 100% sequence identity, predicted to react with Monkey, Gorilla, Chimpanzee, Northern white-cheeked gibbon, and Crab-eating macaque

Target Information

F-Box and WD Repeat Domain Containing 7 (FBXW7) is a member of the F-box protein family characterized by an approximately 40 amino acid motif, the F-box. These proteins form one of the four subunits of the ubiquitin protein ligase complex (SCF: SKP1–Cullin–F-box), functioning in phosphorylation-dependent ubiquitination.
F-box proteins are divided into three classes:

• Fbws: Contain WD-40 domains
• Fbls: Contain leucine-rich repeats
• Fbxs: Contain other interaction modules or no recognizable motifs

FBXW7 (previously FBX30) belongs to the Fbws class and contains seven tandem WD40 repeats. It binds directly to cyclin E and likely targets it for ubiquitin-mediated degradation. Mutations in this gene have been detected in ovarian and breast cancer cell lines, suggesting a role in cancer pathogenesis. Multiple transcript variants encoding different isoforms have been identified.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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