Thermo Fisher Scientific MEF2C Polyclonal Antibody
Rabbit polyclonal antibody targeting human MEF2C, validated for WB, IHC(F), and ICC/IF. Detects endogenous MEF2C involved in muscle, cardiac, and neuronal development. Supplied as liquid, unconjugated, affinity-purified, stored at -20°C in PBS with gly...
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Frozen) (IHC (F)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
Product Specifications
| Property | Description |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthesized peptide derived from human MEF2C (Accession Q06413), corresponding to amino acid residues T370–P420 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2900201 |
Product Specific Information
Antibody detects endogenous levels of total MEF2C.
Target Information
MEF2C is a transcription activator binding to the MEF2 element found in regulatory regions of muscle-specific genes. It controls cardiac morphogenesis, myogenesis, and vascular development. MEF2C plays a critical role in hippocampal-dependent learning and memory by regulating excitatory synapses and synaptic transmission. It is essential for neuronal development, cortical organization, and normal electrical activity. MEF2C also contributes to megakaryocyte and platelet development, bone marrow B lymphopoiesis, and B-cell survival and proliferation. It supports IgG1 antibody responses and germinal center B-cell induction. Isoform 3 and 4, lacking the repressor domain, exhibit higher activity than isoforms 1 and 2.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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