Thermo Fisher Scientific BBS5 Polyclonal Antibody
인간 BBS5 단백질을 인식하는 Rabbit Polyclonal 항체. IHC(P)에서 1:200~1:500 희석으로 사용 가능. 항원 친화 크로마토그래피로 정제되었으며 PBS 기반 완충액에 40% 글리세롤 포함. 단기 4°C, 장기 -20°C 보관 권장.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:200–1:500 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human BBS5. Recombinant protein control fragment (Product # RP-104401) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.05 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2638490 |
Product Specific Information
Immunogen sequence:
DVRFDLSAQQ MKTRPGEVLI DCLDSIEDTK GNNGDRGRLL VTNLRILWHS LALSRVNVSV GYNCILNITT RTANSKLR
Antigen sequence identity:
- Mouse: 92%
- Rat: 92%
Target Information
The BBSome complex functions as a coat complex required for sorting of specific membrane proteins to the primary cilia. It is essential for ciliogenesis but not for centriolar satellite function. This function is mediated in part by the Rab8 GDP/GTP exchange factor, which localizes to the basal body and interacts with the BBSome. Rab8(GTP) promotes ciliary membrane extension. The BBSome associates with the ciliary membrane, binds to RAB3IP/Rabin8 (GEF for Rab8), and facilitates docking and fusion of vesicles to the ciliary membrane base. Together with LTZL1, the BBSome controls SMO ciliary trafficking and contributes to sonic hedgehog (SHH) pathway regulation. It is required for BBSome complex ciliary localization but not for proper complex assembly.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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