Thermo Fisher Scientific MEL18 Polyclonal Antibody
MEL18 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody로, WB 및 IHC(P) 실험에 적합합니다. Protein A로 정제된 액상 시약이며, 인체·마우스·랫트 반응성을 가집니다. 연구용으로만 사용 가능합니다.
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Thermo Fisher Scientific MEL18 Polyclonal Antibody
Applications and Tested Dilutions
- Western Blot (WB): 1:500–1:2,000
- Immunohistochemistry (Paraffin) (IHC (P)): 1:200
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host/Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH conjugated synthetic peptide derived from human MEL18, amino acids 170–210 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | 0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
The protein encoded by this gene contains a RING finger motif and is similar to polycomb group (PcG) gene products. PcG proteins form complexes via protein-protein interactions to maintain transcriptional repression of genes involved in embryogenesis, cell cycle regulation, and tumorigenesis. MEL18 acts as a negative regulator of transcription and exhibits tumor suppressor activity. Expression is detected in various tumor cells but limited in neural tissues under normal conditions. Knockout studies in mice suggest MEL18 may negatively regulate cytokine and chemokine expression, influencing lymphocyte differentiation, migration, and immune responses.
Usage Note
For Research Use Only. Not for use in diagnostic procedures or resale without express authorization.
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