Thermo Fisher Scientific Krt222 Polyclonal Antibody
Thermo Fisher Scientific의 Krt222 폴리클로날 항체는 Human KRT222 단백질을 인식하며, Western blot과 IHC(P)에서 검증되었습니다. 항원 친화 크로마토그래피로 정제된 액상 항체로, 4°C 단기 보관 및 -20°C 장기 보관이 가능합니다. 연구용으로만 사용됩니다.
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 0.04–0.4 µg/mL | – |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:200–1:500 | – |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human Krt222. Recombinant protein control fragment (Product #RP-100329) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.4 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2643210 |
Product Specific Information
Immunogen sequence:
MELSQLLNEI RANYEKILTR NQIETVLSTR IQLEEDISKK MDKDEEALKA AQAELKEARR QWHHLQVEIE SLHA
Antigen sequence identity (orthologs):
- Mouse: 93%
- Rat: 91%
Target Information
KRT222 (also known as KRT222P)
KRT222 is a 295 amino acid protein belonging to the intermediate filament family. The gene encoding KRT222P has been listed as a pseudogene; however, it has not been established that the protein is not translated, and thus it is treated as a protein-coding gene. Two alternatively spliced isoforms exist, and the gene maps to human chromosome 17, which encodes over 1,200 genes and includes key tumor suppressors p53 and BRCA1.
- p53: Maintains genetic integrity through DNA repair and apoptosis regulation; its loss or malfunction is linked to malignant cell growth and Li-Fraumeni syndrome.
- BRCA1: Involved in DNA repair; mutations are associated with early-onset breast and ovarian cancers, as well as cancers of the colon, prostate, and fallopian tubes.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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