Thermo Fisher Scientific COMMD1 Monoclonal Antibody (OTI2E2)
COMMD1 단백질을 인식하는 Thermo Fisher Scientific의 마우스 단일클론 항체로, Western blot, IHC, Flow Cytometry 등에 사용 가능. 고순도 Affinity Chromatography 정제, 1 mg/mL 농도, PBS/BSA/glycerol 저장용액 포함. 연구용으로만 사용.
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Thermo Fisher Scientific COMMD1 Monoclonal Antibody (OTI2E2)
Applications and Tested Dilutions
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:2,000 | - |
| Immunohistochemistry (IHC) | - | View 1 publication |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:150 | - |
| Flow Cytometry (Flow) | 1:100 | - |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Published Species | Human |
| Host / Isotype | Mouse / IgG2a |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI2E2 |
| Immunogen | Full-length human recombinant COMMD1 protein produced in HEK293T cells |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS (pH 7.3) with 1% BSA and 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2723004 |
Target Information
COMMD1 is a proposed scaffold protein involved in diverse physiological processes, including regulation of ubiquitination of specific cellular proteins. It modulates cullin-RING E3 ubiquitin ligase (CRL) complexes by displacing CAND1, promoting CRL E3 activity and dissociating CAND1 from CUL1 and CUL2.
It promotes ubiquitination and proteasomal degradation of NF-κB subunit RELA, down-regulating NF-κB activity. COMMD1 also regulates membrane expression and ubiquitination of SLC12A2, modulates sodium transport in epithelial cells via ENaC subunits, and promotes CFTR surface expression.
It plays roles in copper ion homeostasis and copper-dependent ATP7A trafficking, interacting with CCC and WASH complexes. COMMD1 binds one copper ion per monomer and phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2), and is involved in HIF1A-mediated transcription regulation.
For Research Use Only. Not for use in diagnostic procedures or resale without authorization.
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