Thermo Fisher Scientific Spectrin beta-3 Polyclonal Antibody
인체 Spectrin beta-3 단백질을 표적으로 하는 Thermo Fisher Scientific의 폴리클로날 항체. IHC(P) 적용 가능하며, 항원 친화 크로마토그래피로 정제됨. 4°C 단기 보관 또는 -20°C 장기 보관 권장. 연구용으로만 사용 가능.
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Applications
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:50–1:200
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human Spectrin beta-3 (Product #RP-103863) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2647835 |
Product Specific Information
- Immunogen sequence:
RLWRFLWEVG EAEAWVREQQ HLLASADTGR DLTGALRLLN KHTALRGEMS GRLGPLKLTL EQGQQLVAEG HPGASQASA - Highest antigen sequence identity to the following orthologs:
- Mouse: 95%
- Rat: 95%
Target Information
Spectrins are principal components of a cell’s membrane-cytoskeleton and are composed of two alpha and two beta spectrin subunits.
The protein encoded by this gene (SPTBN2), known as spectrin beta non-erythrocytic 2 or beta-III spectrin, is related to but distinct from the beta-II spectrin gene (SPTBN1).
SPTBN2 regulates the glutamate signaling pathway by stabilizing the glutamate transporter EAAT4 at the plasma membrane surface.
Mutations in this gene cause spinocerebellar ataxia type 5 (SCA5), characterized by neurodegeneration, progressive locomotor incoordination, dysarthria, and uncoordinated eye movements.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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