Thermo Fisher Scientific MKNK2 Monoclonal Antibody (4F11)

Applications

Product Specifications

Product Specific Information

Sequence of this protein is as follows:
MAPEVVEAFS EEASIYDKRC DLWSLGVILY ILLSGYPPFV GRCGSDCGWD RGEACPACQN MLFESIQEGK YEFPDKDWAH ISCAAKDLIS KLLVRDAKQR LSAAQVLQHP WVQGCAPENT LPTPMVLQRW DSHFLLPPHP CRIHVRPGGL VRTVTVNE

Target Information

The Map kinase-interacting kinases (MKNK1 and MKNK2) are activated by Map kinases and regulate protein synthesis by phosphorylating eIF4E on Ser209, potentially contributing to tumorigenesis. Overexpression of Mnk2 increases phosphorylation of endogenous eIF-4E, indicating its role as an eIF-4E kinase in vivo. Mnk2 may be involved in responses to environmental stress and cytokines. Active mutants of MNK1 and MNK2 reduce cap-dependent translation in 293 cells. Human Mnk2 shares ~94% identity with murine Mnk2 and 71% with human Mnk1. In vitro, Mnk2 is a better substrate than Mnk1 for Erk2, p38MAPKα, and p38MAPKβ.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.