Thermo Fisher Scientific MTM1 Polyclonal Antibody
MTM1 단백질을 인식하는 Rabbit Polyclonal 항체로 Western blot에 적합합니다. 인간 MTM1 중간 영역 펩타이드를 면역원으로 사용하였으며, PBS와 2% sucrose buffer에 보관됩니다. -20°C에서 보관하며, 연구용으로만 사용 가능합니다.
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Applications
- Western Blot (WB): 1.0 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide directed towards the middle region of human MTM1 (aa 5–54) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 2% sucrose |
| Contains | 0.09% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2690060 |
Product Specific Information
This target displays homology in the following species:
Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rat: 92%
Target Information
Human MTM1 is a 603 amino-acid protein mutated in myotubular myopathy. The related protein hMTMR2 is mutated in recessive Charcot-Marie-Tooth neuropathy. Myotubularin acts as a lipid phosphatase targeting phosphatidylinositol 3-monophosphate, regulating the PI 3-kinase pathway and membrane trafficking. Wildtype myotubularin can dephosphorylate PI 3-P and PI 4-P in vitro, reducing PI 3-P levels by down-regulating PI 3-K activity and promoting PI 3-P degradation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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