Thermo Fisher Scientific MECP2 Monoclonal Antibody (OTI2F1), TrueMAB
인간 MECP2 단백질을 인식하는 마우스 단클론 항체로, WB 및 IHC(P)에서 검증됨. 고순도 친화 크로마토그래피 정제, PBS/BSA/glycerol 완충액에 보존. MECP2 연구 및 신경발달 질환 관련 기초 연구에 적합.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:150 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI2F1 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 224–486 of human MECP2 produced in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
MECP2 belongs to a family of nuclear proteins (including MBD1, MBD2, MBD3, and MBD4) that contain a methyl-CpG binding domain. MECP2 binds specifically to methylated DNA, a key modification in eukaryotic genomes essential for mammalian development. It represses transcription from methylated gene promoters. Unlike other MBD family members, MECP2 is X-linked and subject to X inactivation. It is dispensable in stem cells but essential for embryonic development. Mutations in the MECP2 gene cause most cases of Rett syndrome, a progressive neurologic developmental disorder and a common cause of mental retardation in females.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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