Thermo Fisher Scientific IRF3 Polyclonal Antibody
Human IRF3 단백질을 인식하는 Rabbit Polyclonal Antibody로, WB, IHC(P), ICC/IF에 적합합니다. 항원 친화 크로마토그래피로 정제되었으며, 액상 형태로 제공됩니다. 단기 4°C, 장기 -20°C 보관을 권장합니다.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.04–0.4 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:200–1:500 |
| Immunocytochemistry (ICC/IF) | 0.25–2 µg/mL |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host/Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human IRF3. Recombinant protein control fragment (Product #RP-102261). |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.2 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping conditions | Wet ice |
| RRID | AB_2789339 |
Product Specific Information
Immunogen sequence:
VNKSRTRFRI PWKHGLRQDA QQEDFGIFQA WAEATGAYVP GRDKPDLPTW KRNFRSALNR KEGLRLAEDR SKDPHDPHKI YEFVNSGVGD FSQPDTSPDT NGGGSTSDTQ EDILDELLGN MVLAPLPDPG PPSLAVAPEP CPQ
Target Information
IRF3 (interferon regulatory factor 3) is a key transcriptional regulator of type I interferon (IFN)-dependent immune responses. It plays a critical role in the innate immune response against DNA and RNA viruses. IRF3 regulates transcription of type I IFN genes (IFN-alpha and IFN-beta) and IFN-stimulated genes (ISG) by binding to an interferon-stimulated response element (ISRE) in their promoters. It acts as a potent activator of the IFN-beta gene and is crucial in both early and late phases of IFNA/B gene induction. IRF3 is found inactive in the cytoplasm of uninfected cells and becomes phosphorylated upon viral infection or toll-like receptor signaling, leading to dimerization and nuclear localization. It associates with CREB binding protein to form DRAF1, which activates transcription of type I IFN and ISG genes. Mutations can result in acute infection-induced encephalopathy.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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