Thermo Fisher Scientific CKMT1B Monoclonal Antibody (2C8)
CKMT1B 단백질을 인식하는 마우스 단클론 항체(클론 2C8). Western blot 및 ELISA에 적합. 인간 시료 반응성. PBS 용액 형태로 제공되며, 보존제 없음. -20°C 보관, 동결·해동 반복 피해야 함.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1–5 µg/mL |
| ELISA | 0.1 ng/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2a, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 2C8 |
| Immunogen | CKMT1B (NP_066270, 327 a.a. ~ 417 a.a.) partial recombinant protein with GST tag (GST tag MW: 26 kDa) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | See Label |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Protein sequence:
GVHIKLPLLS KDSRFPKILE NLRLQKRGTG GVDTAATGGV FDISNLDRLG KSEVELVQLV IDGVNYLIDC ERRLERGQDI RIPTPVIHTK H
Target Information
Mitochondrial creatine (MtCK) kinase is responsible for the transfer of high-energy phosphate from mitochondria to the cytosolic carrier, creatine. It belongs to the creatine kinase isoenzyme family and exists as two isoenzymes: sarcomeric MtCK and ubiquitous MtCK, encoded by separate genes.
Mitochondrial creatine kinase occurs in two different oligomeric forms — dimers and octamers — unlike the exclusively dimeric cytosolic isoenzymes. Overexpression of ubiquitous mitochondrial creatine kinase has been observed in malignant cancers with poor prognosis, possibly related to high energy turnover and failure of apoptosis.
Ubiquitous mitochondrial creatine kinase shares approximately 80% homology with sarcomeric mitochondrial creatine kinase. Two genes located near each other on chromosome 15 encode identical mitochondrial creatine kinase proteins.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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