Thermo Fisher Scientific Human Estrogen Receptor alpha Synthetic Peptide

Applications

Control (Ctrl)

• Assay-dependent

Blocking Assay (BLOCK)

• Assay-dependent

Product Specifications

Product Specific Information

This peptide corresponds to 18 amino acids near the carboxy terminus of ESR1.
PEP-1620 can be used as a blocking peptide with polyclonal antibody PA5-34577.
For use as a blocking peptide in Western blot, incubate the peptide with equal volume of antibody for 30 min at 37ºC.

Target Information

Estrogen Receptors (ER) are members of the steroid/thyroid hormone receptor superfamily of nuclear receptors.
The estrogen receptor is a ligand-activated transcription factor that, when bound to estrogen hormone, induces a conformational change allowing dimerization and binding to estrogen response elements (ERE) in DNA.
When bound to EREs, ER can positively or negatively regulate gene transcription through recruitment of coactivator or corepressor proteins.

There are two different forms of the estrogen receptor, alpha and beta, encoded by separate genes (ESR1 and ESR2, respectively).
Due to alternative RNA splicing, at least four estrogen receptor-alpha isoforms are known to exist:

• Isoform 1 (66 kDa)
• Isoform 2 (53 kDa)
• Isoform 3 (47 kDa)
• Isoform 4 (35 kDa)

Estrogen receptors are widely expressed in different tissue types and are essential for sexual development and reproductive function.
They also play roles in other tissues such as bone and are involved in pathological processes including breast cancer, endometrial cancer, and osteoporosis.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.