Thermo Fisher Scientific PLAUR Polyclonal Antibody
Thermo Fisher Scientific의 PLAUR Polyclonal Antibody는 Human, Mouse, Rat에 반응하는 Rabbit IgG 항체입니다. Western blot, IHC, ICC, Flow cytometry, ELISA 등 다양한 응용에 적합하며, Protein A로 정제된 액상 제품입니다. 세포막 uPAR 단백질 연구용으로 사용됩니다.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:300 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:200 |
| Immunohistochemistry (Frozen) (IHC (F)) | 1:100–1:500 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
| Flow Cytometry (Flow) | 1:20–1:100 |
| ELISA | 1:500–1:1,000 |
Product Specifications
| Property | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH conjugated synthetic peptide derived from human PLAUR, amino acids 201–300 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | 0.01M TBS, pH 7.4, with 1% BSA, 50% glycerol |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
The urokinase-type plasminogen activator receptor (uPAR, also known as PLAUR) regulates cell-surface plasminogen activation and plays an essential role in both normal and pathological processes.
Human PLAUR cDNA encodes 335 amino acids, including a 22-residue signal peptide and a hydrophobic C-terminal region. It forms a glycosylated 50 kDa protein anchored to the plasma membrane via a glycosyl-phosphatidylinositol linkage.
PLAUR interacts with the carbohydrate-binding domain of SELL in neutrophil membranes, similarly to its association with beta-2 integrins. PLAUR-mediated calcium mobilization is SELL dependent.
UPAR mRNA levels correlate with the invasive potential of endometrial carcinomas, showing a 33-fold increase in advanced stages compared to normal tissue. Elevated UPAR expression is linked to recurrence and mortality, suggesting its value as a prognostic marker for advanced endometrial cancer.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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