Thermo Fisher Scientific CACNA1S Polyclonal Antibody
Rabbit polyclonal antibody targeting CACNA1S for IHC, ICC, and ELISA applications. Reacts with human, mouse, and rat samples. Protein A purified and supplied at 1 mg/mL in TBS buffer with glycerol and BSA. Suitable for research use only.
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Thermo Fisher Scientific CACNA1S Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC-P) | 1:200 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
| ELISA | 1:5,000–1:10,000 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH-conjugated synthetic peptide derived from human CACNA1S (amino acids 951–1001) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | 0.01M TBS (pH 7.4) with 50% glycerol, 1% BSA |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | −20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Voltage-sensitive calcium channels mediate calcium entry into excitable cells, playing a crucial role in neurotransmitter release and excitation–contraction (E-C) coupling.
The 1,4-dihydropyridines (DHPs) are synthetic organic compounds used to identify L-type calcium channels found in vertebrate muscle, neuronal, and neuroendocrine cells.
The DHP receptor, part of the L-type calcium channel complex, functions as the voltage sensor in E-C coupling and consists of multiple subunits:
- Alpha-1 subunit: Contains the DHP binding site and shows high sequence homology to voltage-gated sodium channels.
- Alpha-2 subunit: A glycoprotein highly expressed in skeletal and cardiac muscle and brain.
- Beta and gamma subunits: Co-purify with the DHP receptor, contributing to channel structure and function.
For Research Use Only. Not for use in diagnostic procedures or resale without authorization.
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