Thermo Fisher Scientific Phospho-Jak1 (Tyr1022, Tyr1023) Recombinant Rabbit Monoclonal Antibody (Jak1Y10221023-F11)
Recombinant rabbit monoclonal antibody specific for phospho-Jak1 (Tyr1022, Tyr1023). Validated for flow cytometry. High specificity and purity, supplied as liquid form with 0.5 mg/mL concentration. Suitable for research use in human and mouse samples.
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Applications
- Flow Cytometry (Flow)
Tested Dilution
- 1–1,000 ng/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG, kappa |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | Jak1Y10221023-F11 |
| Immunogen | A synthetic phospho-peptide corresponding to residues surrounding Tyr1022/1023 of human phospho-Jak1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS with 0.10% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2897102 |
Additional Formats
Target Information
Janus kinase 1 (JAK1) is a protein tyrosine kinase involved in interferon-alpha/beta and -gamma signal transduction pathways. Immunological stimuli such as interferons and cytokines induce recruitment of Stat transcription factors to cytokine receptor-associated JAK1. JAK1 phosphorylates proximal Stat factors, which dimerize, translocate to the nucleus, and bind to cis elements upstream of target gene promoters to regulate transcription. Upon ligand binding, JAK1 undergoes tyrosine phosphorylation and catalytic activation in an interdependent manner. Phosphorylation of tyrosine residues at positions 1022 and 1023 is believed to function in catalytic activation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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