Thermo Fisher Scientific LXR alpha/beta Polyclonal Antibody
인간 LXR alpha/beta 단백질을 인식하는 염소 유래 폴리클로날 항체로, WB, ICC/IF, Flow Cytometry에 사용 가능. 0.5 mg/mL 농도의 액상 형태이며, TBS(pH 7.3) 버퍼에 0.5% BSA 및 0.02% sodium azide 포함. -20°C에서 보관하며 반복 동결·해동을 피해야 함.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1–3 µg/mL |
| Immunocytochemistry (ICC/IF) | 10 µg/mL |
| Flow Cytometry (Flow) | 10 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Goat / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Internal sequence corresponding to amino acids CRLQDKKLPPLLSEI |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Ammonium sulfate precipitation |
| Storage Buffer | TBS, pH 7.3, with 0.5% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2154884 |
Product Specific Information
This antibody is predicted to react with bovine and canine based on sequence homology.
This antibody is tested in Peptide ELISA: antibody detection limit dilution 32,000.
Target Information
NR1H3 (oxysterols receptor LXR-alpha) is a nuclear receptor that exhibits ligand-dependent transcriptional activation activity. Its interaction with retinoic acid receptor (RXR) shifts RXR from a silent DNA-binding partner to an active ligand-binding subunit, mediating retinoid responses through target genes defined by LXRES.
LXRES are DR4-type response elements characterized by direct repeats of two similar hexanucleotide half-sites spaced by four nucleotides.
NR1H3 plays an important role in cholesterol homeostasis, regulating cholesterol uptake through MYLIP-dependent ubiquitination of LDLR, VLDLR, and LRP8, and functionally interplays with RORA in regulating genes involved in liver metabolism.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
제품 이미지
(이미지 파일: PA1-9066_LXR_alphabeta_P55055-1_Goat.svg)
(이미지 파일: PA1-9066_LXR_alphabeta_Q13133-1_Goat.svg)
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