Thermo Fisher Scientific CD44 Monoclonal Antibody (IL-A118), FITC

Thermo Fisher Scientific CD44 Monoclonal Antibody (IL-A118), FITC

Applications

• Flow Cytometry (Flow)

Tested Dilution: 1:10
Publications: -

Product Specifications

Product Specific Information

Mouse anti-Bovine CD44 antibody, clone IL-A118 recognizes bovine Phagocytic Glycoprotein-1 (PGP-1), also known as CD44, Hermes antigen, Extracellular matrix receptor III, or HUTCH-1.

Target Information

CD44 cell surface antigen is a 100 kDa type 1 transmembrane glycoprotein widely expressed on human leukocytes, white matter of the brain, and certain epithelial cells of the intestine and breast.
Several isoforms of CD44 exist, including the predominant CD44H isoform detected in many normal tissues. CD44 is a receptor for hyaluronic acid (HA) and is involved in cell-cell interactions, adhesion, and migration.
It plays roles in lymphocyte activation, recirculation, and homing. CD44 expression can be up-regulated in some carcinomas, potentially linked to metastatic potential.
CD44 is expressed by hematopoietic and non-hematopoietic cells, epithelial tissues, and filopodia in cultured keratinocytes.
Bone marrow myeloid cells and memory T cells express CD44 at high levels, and peripheral B and T cells can upregulate CD44 expression upon stimulation.
Transcripts for the CD44 gene undergo complex alternative splicing, resulting in many distinct isoforms.
Diseases associated with CD44 dysfunction include superficial keratitis and lichen sclerosus. CD44 may also be related to tumor metastasis formation.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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