Thermo Fisher Scientific Angiopoietin 2 Monoclonal Antibody (21)
인간 Angiopoietin-2에 특이적인 Mouse IgG1 단일클론 항체. ELISA에 적합하며, 고순도 Protein A 정제 및 PBS 버퍼에 보존제 없이 제공. -20°C 보관, 연구용 전용 제품.
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Applications
ELISA
- Tested Dilution: 1:1,000–1:10,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 21 |
| Immunogen | Recombinant Human Angiopoietin-2 Protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2912139 |
Product Specific Information
Specificity: Human Angiopoietin-2
Target Information
ANG-2 binds to the endothelial cell-specific receptor Tie-2, but unlike ANG-1, does not induce tyrosine phosphorylation. Consequently, ANG-2 modulates ANG-1 activation of Tie-2 and can act as either an agonist or antagonist of Tie-2–induced angiogenesis depending on physiological conditions.
The signaling interactions among ANG-1, ANG-2, and Tie-2, along with ANG-3 and ANG-4, are essential for embryonic and adult angiogenesis.
Physiologically, ANG-1 and ANG-2 are associated with sprouting, tube formation, and maintaining structural integrity of new blood vessels.
Mature human ANG-2 is a secreted protein composed of 480 amino acids, featuring an alpha-helix-rich coiled-coil N-terminal domain and a fibrinogen-like C-terminal domain. ANG-2 primarily exists as a disulfide-linked dimer.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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