Thermo Fisher Scientific COX2 Polyclonal Antibody
Rabbit polyclonal antibody against human COX2 for WB and IHC applications. Recognizes COXII with high specificity. Lyophilized form, unconjugated, suitable for research use only. Stable when stored at 4°C short term or -20°C long term.
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Applications
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:200–1:2,000 | - |
| Immunohistochemistry (IHC) | 1:200–1:2,000 | - |
| Miscellaneous PubMed (Misc) | - | View 3 publications |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Published Species | Not Applicable |
| Host / Isotype | Rabbit / Ig |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide to the N-terminal region of human COX2 (Cytochrome c oxidase subunit 2) conjugated to an immunogenic carrier protein was used as the antigen. |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | Not Determined |
| Storage Buffer | Whole serum |
| Contains | No preservative |
| Storage Conditions | Store at 4°C short term. For long-term storage, store at -20°C, avoiding freeze/thaw cycles. Glycerol (1:1) may be added for added stability. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material.
Specificity of this antibody: COXII.
Target Information
COX2 converts arachidonate to prostaglandin H2 (PGH2), a committed step in prostanoid synthesis, including production of inflammatory prostaglandins.
The conversion of arachidonate to PGH2 involves two reactions:
- Cyclooxygenase (COX) reaction: converts arachidonate to prostaglandin G2 (PGG2)
- Peroxidase reaction: reduces PGG2 to prostaglandin H2 (PGH2)
COX2 is constitutively expressed in some tissues under physiological conditions (endothelium, kidney, brain) and up-regulated under pathological conditions such as cancer and inflammation.
Up-regulation is associated with increased cell adhesion, phenotypic changes, resistance to apoptosis, and tumor angiogenesis. In cancer cells, COX2 plays a key role in prostaglandin E2 (PGE2) production, modulating motility, proliferation, and apoptosis resistance.
COX2 is naturally inhibited by calcitriol (active Vitamin D). Glucocorticoids trans-repress PTGS2 gene activity in vivo by interfering with transcription initiation and elongation. COX2 is a target of NSAIDs such as aspirin, which reduce pain and swelling from COX2-driven inflammation.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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