Thermo Fisher Scientific CCR7 Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1:500–1:3,000

Product Specifications

Product Specific Information

• Keep as concentrated solution.
• Predicted reactivity: Mouse (87%), Rat (88%), Pig (93%), Rhesus Monkey (100%), Bovine (95%).
• Positive Control: HeLa, HepG2, MCF-7.
• Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Target Information

CCR7 is a member of the G protein coupled receptor family, which is a subfamily of chemokines.
It was identified to be induced by the Epstein Barr virus (EBV) and is thought to mediate EBV effects on B lymphocytes.
CCR7 is expressed in blood, bone marrow, lymph node, and intestine, particularly in lymphoid tissues and activated B and T lymphocytes.
It controls migration of memory T cells to inflamed tissues and stimulates dendritic cell maturation.
The chemokine ligand CCL19/ECL is a specific ligand of this receptor.
Receptors for the C-C chemokine family include CCR1, CCR2A, CCR3, CCR4, CCR5, and the Duffy blood group antigen, which are important for T cell chemotaxis and migration of phagocytic cells to sites of inflammation.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.