Thermo Fisher Scientific NRXN3 Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1:500–1:1,000

Product Specifications

Target Information

Neurexins comprise a family of neuronal cell surface proteins, including neurexin I (NRXN1), neurexin II (NRXN2), neurexin III (NRXN3), and Caspr (neurexin IV).
Neurexins I–III are expressed as α and β isoforms. The α isoforms consist of three cassettes containing two LNS (Laminin A, Neurexins, Sex hormone-binding) domains separated by EGF domains, followed by a transmembrane region and a 55-amino acid cytoplasmic C-terminal.
The α isoforms bind to neurexophilins at the second LNS site and to the excitatory neurotoxin α-latrotoxin.
The β isoforms contain only one LNS domain, bind to neuroligins, and play a role in the formation and remodeling of synapses.

Caspr (Contactin-Associated Protein 1, also known as Paranodin in mouse) contains an extracellular domain similar to other neurexins and binds to the surface glycoprotein Contactin.
Caspr and Caspr2 (a mammalian homolog of Drosophila Neurexin IV) define distinct subdomains in myelinated axons — Caspr localizes at paranodal junctions, while Caspr2 colocalizes with Shaker-like K⁺ channels in the juxtaparanodal region.
Caspr may play a role in glial–neuron communication during development.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.