Thermo Fisher Scientific DTX2 Polyclonal Antibody
DTX2 단백질을 검출하는 Rabbit Polyclonal Antibody로, 인간 시료에 반응합니다. IHC(P)에서 1:10~1:50 희석으로 사용 가능하며, Notch 신호전달 조절 관련 연구에 적합합니다. 항원 친화 크로마토그래피로 정제된 액상 항체로 -20°C 보관합니다.
- 판매단위
- pk
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Applications
- Immunohistochemistry (Paraffin) (IHC (P)): 1:10–1:50
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Fusion protein corresponding to residues near the C-terminal of human deltex homolog 2 (Drosophila) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.6 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 40% glycerol |
| Contains | 0.05% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2635670 |
Product Specific Information
The antibody detects endogenous levels of total DTX2 protein.
Target Information
DTX2 functions as an E3 ubiquitin ligase and acts as a regulator of Notch signaling, a pathway involved in cell-cell communication and cell-fate determination. It may function as both a positive and negative regulator of Notch depending on developmental and cellular context. DTX2 mediates antineural activity of Notch, possibly by inhibiting transcriptional activation mediated by MATCH1. It functions as an ubiquitin ligase protein in vitro, suggesting its role in regulating the Notch pathway through ubiquitin ligase activity.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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