Thermo Fisher Scientific SGOL1 Polyclonal Antibody

Thermo Fisher Scientific SGOL1 Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Product Specific Information

Positive test controls include: A-549, HT-29, Mouse testis, Rat testis.
The target is usually found in the following locations: Chromosome, Cytoplasm, Nucleus, Centromere, Centrosome, Cytoskeleton, Kinetochore, Microtubule organizing center, Spindle pole.

Immunogen sequence:
SFQDSLEDIK KRMKEKRNKN LAEIGKRRSF IAAPCQIITN TSTLLKNYQD NNKMLVLALE NEKSKVKEAQ DIILQLRKEC YYLTCQLYAL K

Target Information

The protein encoded by this gene is a member of the shugoshin family of proteins. It protects centromeric cohesin from cleavage during mitotic prophase by preventing phosphorylation of a cohesin subunit. Reduced expression leads to premature loss of centromeric cohesion, mis-segregation of sister chromatids, and mitotic arrest.
Evidence suggests protection of cohesin along chromosome arms during mitotic prophase. An isoform lacking exon 6 plays a role in centriole cohesion. Mutations are associated with Chronic Atrial and Intestinal Dysrhythmia (CAID) syndrome, characterized by Sick Sinus Syndrome (SSS) and Chronic Intestinal Pseudo-obstruction (CIPO). Fibroblast cells from CAID patients show increased proliferation and senescence. Pseudogenes exist on chromosomes 1 and 7. Alternative splicing results in multiple transcript variants.

Safety Information

⚠ WARNING: This product can expose you to chemicals including mercury, known to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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