Thermo Fisher Scientific SGOL1 Polyclonal Antibody
SGOL1 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody로, 인간·마우스·랫트에 반응합니다. Western blot, ICC/IF, ELISA에 적합하며 고순도 Affinity Chromatography로 정제되었습니다. 연구용으로만 사용됩니다.
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Thermo Fisher Scientific SGOL1 Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
| ELISA | 1 µg/mL |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fusion protein containing a sequence corresponding to amino acids 10–100 of human SGOL1 (NP_612493.1) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 2.06 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol |
| Contains | 0.01% thimerosal |
| Storage Conditions | −20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2914001 |
Product Specific Information
Positive test controls include: A-549, HT-29, Mouse testis, Rat testis.
The target is usually found in the following locations: Chromosome, Cytoplasm, Nucleus, Centromere, Centrosome, Cytoskeleton, Kinetochore, Microtubule organizing center, Spindle pole.
Immunogen sequence:
SFQDSLEDIK KRMKEKRNKN LAEIGKRRSF IAAPCQIITN TSTLLKNYQD NNKMLVLALE NEKSKVKEAQ DIILQLRKEC YYLTCQLYAL K
Target Information
The protein encoded by this gene is a member of the shugoshin family of proteins. It protects centromeric cohesin from cleavage during mitotic prophase by preventing phosphorylation of a cohesin subunit. Reduced expression leads to premature loss of centromeric cohesion, mis-segregation of sister chromatids, and mitotic arrest.
Evidence suggests protection of cohesin along chromosome arms during mitotic prophase. An isoform lacking exon 6 plays a role in centriole cohesion. Mutations are associated with Chronic Atrial and Intestinal Dysrhythmia (CAID) syndrome, characterized by Sick Sinus Syndrome (SSS) and Chronic Intestinal Pseudo-obstruction (CIPO). Fibroblast cells from CAID patients show increased proliferation and senescence. Pseudogenes exist on chromosomes 1 and 7. Alternative splicing results in multiple transcript variants.
Safety Information
⚠ WARNING: This product can expose you to chemicals including mercury, known to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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