Thermo Fisher Scientific Bcr Polyclonal Antibody
Human 및 Mouse 시료에서 Bcr 단백질 검출용 Rabbit Polyclonal Antibody. Western blot과 Immunocytochemistry에 적합. 고순도 Affinity chromatography 정제, 1 mg/mL 농도, 안정적 PBS/glycerol buffer. 연구용으로만 사용 가능.
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:2,000
Immunocytochemistry (ICC/IF)
- Tested Dilution: 1:100–1:500
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human BCR (Accession P11274), corresponding to amino acid residues V151–S201 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2818438 |
Product Specific Information
Antibody detects endogenous levels of total Bcr.
Target Information
A reciprocal translocation between chromosomes 22 and 9 produces the Philadelphia chromosome, often found in patients with chronic myelogenous leukemia.
The chromosome 22 breakpoint for this translocation is located within the BCR gene, producing a fusion protein encoded by sequences from both BCR and ABL genes.
Although the BCR-ABL fusion protein has been extensively studied, the function of the normal BCR gene product remains unclear.
The protein exhibits serine/threonine kinase activity and acts as a GTPase-activating protein for p21rac.
Two transcript variants encoding different isoforms have been identified for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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