Thermo Fisher Scientific PIF1 Polyclonal Antibody
PIF1 단백질을 인식하는 Rabbit Polyclonal 항체로, Western blot, IHC, ICC/IF 등에 사용 가능. 인간 PIF1 단백질의 내부 펩타이드(400-500 aa)로부터 제작됨. 항원 친화성 크로마토그래피로 정제되었으며, PBS와 30% 글리세롤 용액 형태로 제공. 연구용 전용 제품.
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Applications
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | Assay-Dependent | - |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:300 | - |
| Immunocytochemistry (ICC/IF) | Assay-Dependent | - |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide made to an internal portion of the human PIF1 protein (between residues 400–500) [UniProt Q9H611] |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1.16 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | PBS with 30% glycerol |
| Contains | 0.05% sodium azide |
| Storage conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping conditions | Wet ice |
| RRID | AB_2718843 |
Target Information
PIF1 is a single-stranded (ss) DNA-dependent ATPase as well as a DNA helicase that unwinds DNA in a 5′ to 3′ direction with respect to the DNA strand on which it binds first. This protein is critical to DNA replication and telomere length maintenance in Saccharomyces cerevisiae. The PIF1 gene is highly conserved from yeast to humans. Mutations in the gene that encodes for PIF1 cause all telomeres to lengthen, suggesting that PIF1 functions as a catalytic inhibitor of both new telomere formation and telomere elongation. Human PIF1 preferentially binds telomeric DNA where it inhibits telomerase activity. PIF1 specifically counteracts the RecQ homolog Sgs1 helicase activity, and degradation of PIF1 is mediated by the ubiquitin–26S proteasome pathway.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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