Thermo Fisher Scientific Cyclin B1 Polyclonal Antibody
Cyclin B1 단백질을 인식하는 Rabbit Polyclonal 항체로, 세포 주기 G2/M 전이 연구에 적합합니다. Western blot과 IHC(Paraffin)에서 검증되었으며, 고순도의 Protein A 및 항원 친화 크로마토그래피로 정제되었습니다. 마우스 반응성, 액상 형태로 제공됩니다.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:25 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH conjugated synthetic peptide between 103–130 amino acids from the central region of mouse CCNB1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.32 mg/mL |
| Purification | Protein A, Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.4 |
| Contains | 0.09% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2552555 |
Product Specific Information
This antibody is predicted to react with hamster based on sequence homology.
Target Information
Cyclins bind to and regulate the activity of Cyclin dependent protein kinases (CDKs).
Cyclin B1 (CCNB1) is a regulatory protein essential for the control of the cell cycle at the G2/M transition. It forms a complex with p34 (cdc2) to create the maturation-promoting factor (MPF).
Two alternative transcripts exist — one constitutively expressed and another cell cycle-regulated, predominantly during G2/M phase.
Cyclin B1 accumulates steadily during G2 phase and is rapidly degraded at the end of mitosis via APC-dependent destruction.
Overexpression of Cyclin B1 has been observed in several cancers, including breast, prostate, and non-small cell lung cancer.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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