Thermo Fisher Scientific TMPRSS11F Polyclonal Antibody
TMPRSS11F 단백질을 인식하는 Rabbit Polyclonal Antibody로, Western Blot 및 IHC(Paraffin) 실험에 적합. 인간 및 마우스 시료 반응성. 항원 친화 크로마토그래피로 정제된 2 mg/mL 액상 시약. 연구용으로만 사용.
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- PA550846
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- pk
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:100–1:200 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to residues near the C-terminal of human transmembrane protease, serine 11F |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 2 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 40% glycerol |
| Contains | 0.05% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2636298 |
Product Specific Information
The antibody detects endogenous levels of total TMPRSS11F protein.
Target Information
TMPRSS11F is a type-II transmembrane protease, similar to hepsin (TMPRSS1). It belongs to a family of membrane-attached serine proteases including TMPRSS11A–F, Hepsin, Corin, and Matriptase-1, 2, and 3.
TMPRSS11F has the following domain structure:
- Aminoterminal cytoplasmic domain
- Transmembrane domain
- SEA domain (Sea urchin sperm protein, Enterokinase, Agrin)
- Short spacer
- Trypsin-like serine protease domain
The SEA domain may play a role in carbohydrate binding, although its function in TMPRSS11F remains unclear. Cleavage at the Arg206–Ile207 bond is thought to liberate the catalytic domain.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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