Thermo Fisher Scientific TTC3 Polyclonal Antibody
Human TTC3 단백질을 인식하는 Rabbit Polyclonal Antibody로 IHC(P) 검증 완료. 액상 형태, 항원 친화 크로마토그래피로 정제됨. PBS 및 40% glycerol buffer에 보존, 연구용으로만 사용 가능.
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Applications
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:20–1:50
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human TTC3. Recombinant protein control fragment (Product #RP-91795) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2649059 |
Product Specific Information
Immunogen sequence:
DCPHVDDCVF AAEFMSNDYV RVTQLYCDGV GVQYKDYIQS ERNLEFDICS IWCSKPISVL QDYCDAIKIN IFWPLLFQHQ NSSVISRLHP CVDANNSRAS EINLKKLQHL ELMEDIVDLA KKVANDS
Highest antigen sequence identity to the following orthologs:
- Mouse: 77%
- Rat: 77%
Target Information
E3 ubiquitin-protein ligase which catalyzes the formation of Lys-48-polyubiquitin chains (PubMed:20059950, PubMed:30696809).
Mediates the ubiquitination and subsequent degradation of phosphorylated Akt (AKT1, AKT2, AKT3) in the nucleus.
Acts as a terminal regulator of Akt signaling after activation and positively regulates TGFB1-induced epithelial-mesenchymal transition and myofibroblast differentiation.
Regulates neuronal differentiation via actin remodeling and Golgi organization through a signaling cascade involving RHOA, CIT, and ROCK.
Inhibits cell proliferation. [UniProt]
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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