Thermo Fisher Scientific ITIH4 Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Product Specific Information

Immunogen sequence:
RLAILPASAP PATSNPDPAV SRVMNMKIEE TTMTTQTPAP IQAPSAILPL PGQSVERLCV DPRHRQGPVN LLSDPEQGVE VTGQYEREKA GFSWIEVTFK NPLVWVHASP EHVVVTRNRR SSAYKWKETL FSVMPGLKMT MDKTGLLLLS DPDKVTIGLL FWDGRGEGLR LLLRDTDRFS SHVGGTLGQF YQEVLWGSPA ASDDGRRTLR VQGNDHSATR ERRLDYQEGP PGVEISCWSV EL

Positive Samples: LO2, A-549

Target Information

The inter-alpha-trypsin inhibitor (ITI, I-alpha-I) family is a classic example of protein-glycosaminoglycoprotein (PGP) complexes. They occur constitutively in plasma at relatively high concentrations and result from alternating combinations of three kinds of heavy chains with a common light chain called the bikunin proteoglycan. Bikunin has two proteinase inhibitor domains and belongs to the Kunitz-type protease inhibitor family; it displays inhibitory activity against trypsin, leukocyte elastase, and plasmin. The heavy chains do not have protease inhibitory properties but can interact with hyaluronic acid, promoting extracellular matrix stability. The ITI protein family is suspected of playing a key role in extracellular matrix biology.

⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.