Thermo Fisher Scientific ITIH4 Polyclonal Antibody

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:2,000

-

ELISA (ELISA)

1 µg/mL

-

Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant fusion protein containing a sequence corresponding to amino acids 689-930 of human ITIH4 (NP_0022092) if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:ITIH4,uniProtId:Q14624-1,ncbiNodeId:9606,antigenRange:689-930,antigenLength:930,antigenImageFileName:PA5-88768_ITIH4_Q14624-1_Rabbit.svg,antigenImageFileNamePDP:PA5-88768_ITIH4_Q14624-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.9 mg/mL

Purification

Affinity Chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.01% thimerosal

Storage conditions

-20° C, Avoid Freeze/Thaw Cycles

Shipping conditions

Wet ice

RRID

AB_2805117

Product Specific Information

Immunogen sequence: RLAILPASAP PATSNPDPAV SRVMNMKIEE TTMTTQTPAP IQAPSAILPL PGQSVERLCV DPRHRQGPVN LLSDPEQGVE VTGQYEREKA GFSWIEVTFK NPLVWVHASP EHVVVTRNRR SSAYKWKETL FSVMPGLKMT MDKTGLLLLS DPDKVTIGLL FWDGRGEGLR LLLRDTDRFS SHVGGTLGQF YQEVLWGSPA ASDDGRRTLR VQGNDHSATR ERRLDYQEGP PGVEISCWSV EL; Positive Samples: LO2, A-549

Target Information

The inter-alpha-trypsin inhibitor (ITI, I-alpha-I) family is a classic example of protein-glycosaminoglycoprotein (PGP) complexes. They occur constitutively in plasma at relatively high concentrations and results from alternating combinations of three kinds of heavy chains with a common light chain called the bikunin proteoglycan. Bikunin has two proteinase inhibotor domains and belongs to the Kunitz-type protease inhibitor family; it displays an inhibitory activity against trypsin, leukocyte elastase and plasmin. The heavy chains do not have any protease inhibitory properties but have the capacity to interact in vitro and in vivo with hyaluronic acid and this binding promotes the stability of the extra-cellular matrix. The ITI protein family is suspected of playing a key role in the extra-cellular matrix biology.

⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.