Thermo Fisher Scientific DTX3L Polyclonal Antibody
Rabbit polyclonal antibody recognizing human DTX3L. Validated for Western blot applications. Supplied as liquid form, 1 mg/mL concentration, purified by antigen affinity chromatography. Recommended positive controls include 293T, A431, and Jurkat cell ...
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:3,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fragment corresponding to a region within amino acids 23–242 of Human DTX3L |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7, with 1% BSA, 20% glycerol |
| Contains | 0.01% thimerosal |
| Storage Conditions | Store at 4°C short term. For long term, store at −20°C. Avoid freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2548165 |
Product Specific Information
- Recommended positive controls: 293T, A431, Jurkat
- Store product as a concentrated solution.
- Centrifuge briefly prior to opening the vial.
Target Information
DTX3L is a component of the shelterin complex (telosome) involved in the regulation of telomere length and protection. Shelterin binds to double-stranded TTAGGG repeats added by telomerase, protecting chromosome ends from DNA damage responses. It promotes binding of POT1 to single-stranded telomeric DNA and modulates POT1’s inhibitory effects on telomere elongation. The ACD-POT1 heterodimer enhances telomerase processivity and telomere elongation and may also play a role in organogenesis.
⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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