Thermo Fisher Scientific TARDBP TAR DNA binding protein/TDP43 Monoclonal Antibody (TARDP/349)
TARDBP/TDP43 단백질을 인식하는 Thermo Fisher Scientific의 mouse monoclonal 항체. Western blot, IHC, ELISA에 적합하며 인간 시료 반응성. 단백질 A/G 정제, 4°C 보관, 연구용 전용.
- 카탈로그번호
- 23435-MSM1-Px (2개 옵션)
- 판매단위
- pk
카탈로그
2개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다Thermo Fisher Scientific · Thermo Fisher Scientific TARDBP TAR DNA binding protein/TDP43 Monoclonal Antibody (TARDP/349)
Thermo Fisher Scientific TARDBP TAR DNA Binding Protein/TDP43 Monoclonal Antibody (TARDP/349)
Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 2–4 µg/mL |
| Immunohistochemistry (Paraffin) (IHC-P) | 1–2 µg/mL |
| ELISA | 2–4 µg/mL |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | TARDP/349 |
| Immunogen | Recombinant fragment within human TDP43 (aa 200 to C-terminus) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS with 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Positive Control: Human cerebrum or colon
- Cellular Location: Absent from nucleus of affected neurons; primary component of cytoplasmic ubiquitin inclusions; nucleus localization in normal cells. Observed in frontotemporal lobar degeneration and amyotrophic lateral sclerosis.
Target Information
TDP43 was first identified as a novel cellular protein that binds to HIV-1 TAR DNA sequence motifs and acts as a transcriptional repressor of the HIV-1 LTR. It also regulates splicing of exon 9 of the cystic fibrosis transmembrane conductance regulator (CFTR), likely via association with UG repeats at the 3′ splice site. Pathologic TDP43 (hyperphosphorylated, ubiquitinated, and cleaved form) is the major disease protein in ubiquitin-positive, tau- and alpha-synuclein-negative frontotemporal dementia (FLTD-U). TDP43 is distinct from TRBP1, an RNA-binding protein that binds HIV-1 TAR RNA sequences.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Thermo Fisher Scientific 상품 둘러보기
전체보기
문의
0개 · 배송·재고 문의는 실시간 상담이 빠릅니다아직 등록된 문의가 없어요.