Thermo Fisher Scientific TARDBP TAR DNA binding protein/TDP43 Monoclonal Antibody (TARDP/349)

Thermo Fisher Scientific TARDBP TAR DNA Binding Protein/TDP43 Monoclonal Antibody (TARDP/349)

Applications and Tested Dilutions

Product Specifications

Product Specific Information

• Positive Control: Human cerebrum or colon
• Cellular Location: Absent from nucleus of affected neurons; primary component of cytoplasmic ubiquitin inclusions; nucleus localization in normal cells. Observed in frontotemporal lobar degeneration and amyotrophic lateral sclerosis.

Target Information

TDP43 was first identified as a novel cellular protein that binds to HIV-1 TAR DNA sequence motifs and acts as a transcriptional repressor of the HIV-1 LTR. It also regulates splicing of exon 9 of the cystic fibrosis transmembrane conductance regulator (CFTR), likely via association with UG repeats at the 3′ splice site. Pathologic TDP43 (hyperphosphorylated, ubiquitinated, and cleaved form) is the major disease protein in ubiquitin-positive, tau- and alpha-synuclein-negative frontotemporal dementia (FLTD-U). TDP43 is distinct from TRBP1, an RNA-binding protein that binds HIV-1 TAR RNA sequences.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.