Thermo Fisher Scientific BNIP2 Polyclonal Antibody

Applications

Tested Dilution

Publications

Western Blot (WB)

0.04-0.4 µg/mL

-

Immunohistochemistry (Paraffin) (IHC (P))

1:200-1:500

-

Product Specifications

Species Reactivity

Human, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant protein corresponding to Human BNIP2. Recombinant protein control fragment (Product #RP-90795). if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:BNIP2,uniProtId:Q12982-1,ncbiNodeId:9606,antigenRange:4-142,antigenLength:314,antigenImageFileName:PA5-55438_BNIP2_Q12982-1_Rabbit.svg,antigenImageFileNamePDP:PA5-55438_BNIP2_Q12982-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.2 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.2, with 40% glycerol

Contains

0.02% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Wet ice

RRID

AB_2638571

Product Specific Information

Immunogen sequence: VELKEEWQDE DFPIPLPEDD SIEADILAIT GPEDQPGSLE VNGNKVRKKL MAPDISLTLD PSDGSVLSDD LDESGEIDLD GLDTPSENSN EFEWEDDLPK PKTTEVIRKG SITEYTAAEE KEDGRRWRMF RIGEQDHRV

Highest antigen sequence identity to the following orthologs: Mouse - 88%, Rat - 88%.

Target Information

BNIP-2, (previously designated Nip2 and Nip21 in human and mouse respectively), shares homology with the non-catalytic domain of Cdc42 GTPase-activating protein (Cdc42GAP). Through binding to Cdc42GAP, BNIP-2 enhances the GTPase activity of Cdc42GAP, facilitating the hydrolysis of GTP bound to Cdc42 and thereby, mediating the signaling pathways involving receptor kinases, small GTPases and apoptotic proteins. Nix, which is also designated Nip3L or Bnip3L, is highly related to BNIP-3, and both proteins localize to the mitochondria where they associate with Bcl-2 proteins.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.